TIMC lab "Translational Research and Innovation in Medicine and Complexity"

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Scientific domain LS5: Neuroscience and Disorders of the Nervous System LS2: Integrative Biology: from Genes and Genomes to Systems LS4: Physiology in Health Disease and Ageing LS7: Prevention Diagnosis and Treatment of Human Diseases LS3: Cellular Developmental and Regenerative Biology LS6: Immunity Infection and Immunotherapy
Keywords Animal experimentation Computational biology and medicine
Home partner institution (Grenoble INP - UGA) Grenoble Institute of Technology
Website

Website

Technical staff available Yes
Remote access details No
Remote access available No
Open to external users Yes
Equipment

Computational Biology and Modelling (BCM) team, Cell and Tissue Imaging Platform:

  • Confocal laser scanning microscope Zeiss LSM710 with thermostatic chamber and CO2
  • Liquid Phase Atomic Force Microscope (AFM)
  • Lyncéetech Digital Holographic Microscope (with epifluorescence)
  • Bioluminescence microscope
  • Automated Video-microscopy (epifluorescence) station for long-term monitoring
  • Coherent Optical Tomography (OCT) Microscope

Theoretical and Applied Experimental Cardio-Respiratory Physiology (PRETA) team:

  • Respiratory gas analyser
  • Non-invasive blood pressure monitoring
  • ECG and foetal heart sounds
  • Electroglottography
  • Multi-sensor chest belts
  • Respiratory Inductance Plethysmography
  • Pneumotachograph
  • Cardiac impedancemetry
  • Small Animal Set: Non-invasive cardio-respiratory monitoring by plethysmography (DECRO®)

Health, Plasticity, Motricity (SPM) team:

  • 32-channel data acquisition system (12-bit A/D)
  • Kinematic motion analysis in 3D without wires
    • Opto-electronic systems (optotrak + codamotion)
    • Accelerometers
    • 3D video system
    • Goniometers
    • 9-channel inertial units
  • Surface electromyography – 128-channel EEG –Force platforms (static and dynamic) –GAITRite walking mat –Treadmill
  • Sensors and other devices: strain gauges, ground contacts, tendon vibrators, etc.

Computer Assisted Medico-surgical Gestures (GMCAO) team, Excellence Centre for Computer Assisted Medical Interventions (ECCAMI):

  • Station, measurement table, phantoms
  • Access:
    • To operating theatres at the university hospital centre of Grenoble, equipped with innovative medical devices, to the technological showcase through a live video transmission system
    • To the anatomy laboratory of UGA
    • To a comprehensive view of GMCAO techniques
    • To the hardware and software platform: motorized C-Arm, digital detector, laparoscopy and elastography station (…), software licenses (ANSYS mechanical calculation, CamiTK rapid prototyping)

Translational microbial Evolution and Engineering (TrEE) team:

  • Experimental Infectiology Platform (PIE)
    • Olympus IX81 Motorized Inverted Fluorescence Microscope
    • ORCA ER B&W CCD camera
    • Temperature-controlled incubator
    • ScanR high-speed analysis software
  • Mass spectrometry metabolomics platform (GExiM)
    • Chromatography system: Vanquich Flex Binary W/O Det
    • Mass spectrometer: Q Exactive Plus with enhanced resolution mode. System with Ion Max Source, H-ESI II probe, Chemyx Fusion 100 syringe pump and Rheodyne 6-Port Valve.
      • Mass range: 50 to 6000 Da
      • Resolution of 140,000 at mass m/z 200 and a scan speed of 1.5 Hz, 17500 at mass m/z 200 at 12 Hz
      • Mass accuracy: 5 ppm
      • Sensitivity: sub femtomole for peptides, 500fg of Buspirone on column,
      • Full MS: S/N 100: 1 and in SIM mode: 50 fg Buspirone, on column S / N 100: 1
  • Nitrogen generator: Nitrogen Generator Genius 1022 (Peak Scientific)
Open access to updated information database No
Online booking system details No
Online booking system available Yes
Description

The TIMC “Translational Research and Innovation in Medicine and Complexity” laboratory brings together scientists and clinicians around the use of computer science and applied mathematics for the understanding and control of normal and pathological processes in biology and health.

Its interdisciplinary activity contributes both to basic knowledge in these fields and to the development of systems for diagnostic and therapeutic support.

TIMC has around 300 members spread over 11 research teams, including around 160 permanent staff: researchers, teacher-researchers, engineers, technicians and administrative staff. Each year, it welcomes nearly 70 doctoral and post-doctoral students.